HYDROCHLOROTHIAZIDE (hye DROE klor oh THYE a zide) treats high blood pressure. It may also be used to reduce swelling related to heart, kidney, or liver disease. It works by helping your kidneys remove more fluid and salt from your blood through the urine. It belongs to a group of medications called diuretics.
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
Diabetes
Gout
Kidney disease
Liver disease
Lupus
An unusual or allergic reaction to hydrochlorothiazide, other medications, foods, dyes, or preservatives
Pregnant or trying to get pregnant
Breastfeeding
How should I use this medication?
Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.
Talk to your care team about the use of this medication in children. While it may be prescribed for children for selected conditions, precautions do apply.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medication?
Do not take this medication with any of the following:
Cidofovir
Dofetilide
Tranylcypromine
This medication may also interact with the following:
Cholestyramine
Colestipol
Digoxin
Lithium
Medications for diabetes
NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen
Other medications for blood pressure
What side effects may I notice from receiving this medication?
Side effects that you should report to your care team as soon as possible:
Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
Gout—severe pain, redness, warmth, or swelling in joints, such as the big toe
Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
Low potassium level—muscle pain or cramps, unusual weakness, fatigue, fast or irregular heartbeat, constipation
Sudden eye pain or change in vision such as blurred vision, seeing halos around lights, vision loss
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Change in sex drive or performance
Headache
Upset stomach
What should I watch for while using this medication?
Visit your care team for regular checks on your progress. Check your blood pressure as directed. Know what your blood pressure should be and when to contact your care team.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
Taking this medication is only part of a total heart healthy program. Ask your care team if there are other changes you can make to improve your overall health.
Do not treat yourself for coughs, colds, or pain while you are using this medication without asking your care team for advice. Some medications may increase your blood pressure.
Talk to your care team about your risk of skin cancer. You may be more at risk for skin cancer if you take this medication. To lower your risk, keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use sun lamps, tanning beds, or tanning booths.
This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.
Where should I keep my medication?
Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light and moisture. Keep the container tightly closed. Do not freeze. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix it with cat litter, dirt, coffee grounds, or another unwanted substance. Seal the mixture in a bag or container. Put it in the trash.
K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.
This information is educational only and should not be construed as specific instructions for individual patients nor as a substitute for medical advice, diagnosis or treatment. Talk to your health care provider or pharmacist about the information and instructions. K Health assumes no liability for any use or reliance on this information.
