Azithromycin is one of the most common antibiotics prescribed to treat bacterial infections.
It works by preventing further growth and multiplication of bacteria in the body.
However, there’s a lot about this medication you will want to know if your doctor or health care provider prescribes it to you.
While using azithromycin, you may wonder if it’s safe to take it with your favorite alcoholic drink or if you have to skip drinking alcohol to keep the medicine effective.
What is Azithromycin?
Azithromycin is a macrolide antibiotic that treats bacterial infections by stopping the growth of bacteria in the body. It is only available with a prescription from a doctor or health care provider.
Azithromycin treats bacterial infections such as:
- Community-acquired pneumonia
- Lyme disease
- Middle ear infection (otitis media) in those with allergies to other options
- Bacterial bronchitis
Because it is an antibiotic, azithromycin does not work for viral or fungal infections.
Avoid unnecessary use of azithromycin to prevent the development of antibiotic resistance.
Antibiotic resistance means the drug is no longer effective against the bacteria.
What Happens When You Mix Alcohol and Azithromycin?
There is no known adverse interaction between alcohol and azithromycin.
However, this does not mean that mixing both is a good idea.
Mixing azithromycin and alcohol can worsen the medication’s side effects, leading to one or more of the following problems:
Liver toxicity is one of the severe side effects of using azithromycin.
The liver is the main organ that eliminates azithromycin.
It is also the organ responsible for processing alcohol.
When you consume both substances together, it takes a toll on your liver, increasing the risk of liver damage.
Some symptoms of liver issues are:
If you have a pre-existing liver condition, discuss this with your doctor or pharmacist.
They will usually find an alternative antibiotic to prescribe or monitor you closely for symptoms.
Nausea, vomiting, diarrhea
Generally, antibiotics are known to cause gastrointestinal upset.
Consuming alcohol will increase the risk of an upset stomach.
This means that you have a higher chance of experiencing these symptoms intensely than you would with only azithromycin.
Frequent vomiting can reduce the effectiveness of your medication since less than the prescribed concentration is absorbed into your bloodstream.
Headache or lightheadedness
People who use azithromycin may suffer from headaches.
Alcohol is also known to cause headaches in some patients.
It can become challenging to know whether you’re experiencing side effects from the medication or the alcohol.
The same applies to feeling lightheadedness or dizziness. It is also common among those who consume large quantities of alcohol.
Consuming alcohol while on azithromycin is only likely to compound headaches.
Alcohol is known to suppress the immune system which helps to fight off infections, including bacterial infections.
If the immune system is weak, it is harder to fight the infection, slowing the healing process.
Since alcohol worsens the severity of azithromycin side effects, you tend to feel worse even when you should be feeling better.
Other Possible Side Effects
Other possible side effects of mixing alcohol and azithromycin are:
- Dehydration: Because alcohol is a diuretic, it makes you lose fluid from your body faster, leaving you dehydrated. Dehydration can make you feel worse.
- Hides serious side effects: The side effects of alcohol consumption are similar to those of using azithromycin, so it can be challenging to know which substance is causing the symptoms. This can make it harder to decide the next course of action.
Other Substances that Interact with Azithromycin
Drug interactions exist and in such cases, the use of one drug affects the efficacy of the other drug used by the same patient.
Some other substances that interact with azithromycin include:
- Antacids containing magnesium hydroxide or aluminum hydroxide
- Nelfinavir used in the treatment of HIV
- Migraine medication like ergotamine
- Blood thinners like warfarin
- Gout medication like colchicine
- Amiodarone used for treating irregular heartbeat
These drugs should ideally not be used with azithromycin.
In some rare cases, the doctor will resort to dosage adjustment or careful monitoring of the patient.
When to See a Doctor
If you think you have a bacterial infection, speak with a doctor who will then decide whether you need azithromycin or any other medication.
You must present a doctor’s prescription before you can purchase azithromycin.
While using azithromycin, if you experience any side effects, make sure to speak with your doctor.
Even if you think the side effects are a result of your alcohol intake, still make the call.
Based on the severity of the reaction, your doctor or health care provider will then decide whether you should discontinue the drug or advise you on how to manage the symptoms.
How K Health Can Help
Curious about how to manage the side effects of mixing azithromycin and your favorite alcoholic beverage? You should speak to a doctor.
Did you know you can get affordable virtual primary care with K Health?
Check your symptoms, explore conditions and treatments, and if needed, text with a healthcare provider in minutes.
K Health’s AI-powered app is HIPAA compliant and is based on 20 years of clinical data.
Frequently Asked Questions
K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.
K Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.